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Regulating Higher‐Order Organization through the Synergy of Two Self‐Sorted Assemblies
Author(s) -
Ji Wei,
Zhang Shijin,
Yukawa Sachie,
Onomura Shogo,
Sasaki Toshio,
Miyazawa Kun'ichi,
Zhang Ye
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201712575
Subject(s) - scaffold , extracellular matrix , nanofiber , self assembly , nanotechnology , molecule , peptide , biophysics , nanostructure , chemistry , layer (electronics) , materials science , biochemistry , organic chemistry , computer science , biology , database
The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher‐order molecular self‐assembly (SA), mediated through the dynamic growth of scaffold‐like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self‐sorted coumarin‐based gelators, a peptide molecule and a benzoate molecule, which self‐assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer‐by‐layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher‐order architecture.