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Highly Fluorescent Chiral N‐S‐Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism
Author(s) -
Li Feng,
Li Yiye,
Yang Xiao,
Han Xuexiang,
Jiao Yang,
Wei Taotao,
Yang Dayong,
Xu Huaping,
Nie Guangjun
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201712453
Subject(s) - cysteine , fluorescence , chemistry , nanomaterials , metabolism , biophysics , quantum dot , carbon fibers , quantum yield , biochemistry , nanotechnology , materials science , biology , physics , quantum mechanics , composite number , composite material , enzyme
Cysteine‐based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N‐S‐doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l ‐ or d ‐cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high‐temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l ‐CDs showed up‐regulated glycolysis, while d ‐CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.