Premium
Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis
Author(s) -
Wang Meng,
Chen Jun,
Chen Zongjia,
Zhong Changxu,
Lu Ping
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201711845
Subject(s) - desymmetrization , enantioselective synthesis , enamine , chemistry , palladium , intramolecular force , catalysis , aryl , organocatalysis , combinatorial chemistry , stereochemistry , organic chemistry , alkyl
Abstract The enantioselective intramolecular α‐arylation of cyclobutanones has been established by combining palladium and enamine catalyst systems. Two different enantioselective control strategies have been developed for cyclobutanone substrates bearing O‐ or N‐tethered aryl bromides. Further synthetic applications are also reported.