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Total Synthesis of Bryostatin 8 Using an Organosilane‐Based Strategy
Author(s) -
Zhang Yuebao,
Guo Qianyou,
Sun Xianwei,
Lu Ji,
Cao Yanjun,
Pu Qiang,
Chu Zhiwen,
Gao Lu,
Song Zhenlei
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201711452
Subject(s) - geminal , silane , chemistry , prins reaction , ring (chemistry) , stereochemistry , molecule , organic chemistry , catalysis
Convergent total synthesis of bryostatin 8 has been accomplished by an organosilane‐based strategy. The C ring is constructed stereoselectively through a geminal bis(silane)‐based [1,5]‐Brook rearrangement, and the B ring through geminal bis(silane)‐based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule.