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(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster
Author(s) -
Zeng Xiaojun,
Li Junling,
Ng Chin K.,
Hammond Gerald B.,
Xu Bo
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201711341
Subject(s) - chemistry , nucleophile , cluster (spacecraft) , atmosphere (unit) , hydrogen bond , functional group , group (periodic table) , hydrogen , molecule , organic chemistry , catalysis , computer science , physics , operating system , polymer , thermodynamics
We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF( 18 F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18 F addition to C−C unsaturated bonds proceeded with extraordinarily high radiochemical yields.