Borazine‐CF 3  −  Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation | Zendy

Geri Jacob B. | Zendy; Wade Wolfe Michael M. | Zendy; Szymczak Nathaniel K. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Borazine‐CF 3 − Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation

Author(s) -

Geri Jacob B.,

Wade Wolfe Michael M.,

Szymczak Nathaniel K.

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201711316

Subject(s) - trifluoromethylation , electrophile , borazine , chemistry , nucleophile , reagent , yield (engineering) , photochemistry , adduct , catalysis , organic chemistry , combinatorial chemistry , inorganic chemistry , trifluoromethyl , materials science , alkyl , boron nitride , metallurgy

A fluoroform‐derived borazine CF 3 − transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C−H and C−X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF 3 − transfer, and cation modification afforded a reagent with enhanced stability.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research