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Distal Weak Coordination of Acetamides in Ruthenium(II)‐Catalyzed C−H Activation Processes
Author(s) -
Bu Qingqing,
Rogge Torben,
Kotek Vladislav,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201711108
Subject(s) - ruthenium , catalysis , chemistry , electrophile , alkyne , combinatorial chemistry , coordination complex , medicinal chemistry , metal , organic chemistry
C−H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C−H functionalization offers ample scope—including twofold oxidative C−H functionalizations and alkyne hydroarylations—through facile base‐assisted internal electrophilic‐type substitution (BIES) C−H ruthenation by weak O ‐coordination.
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