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Direct Dehydroxytrifluoromethoxylation of Alcohols
Author(s) -
Jiang Xiaohuan,
Deng Zhijie,
Tang Pingping
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201711050
Subject(s) - chemistry , trifluoromethyl , reagent , nucleophile , alkyl , organic chemistry , trifluoromethylation , combinatorial chemistry , molecule , nucleophilic substitution , catalysis
The first example of a direct dehydroxytrifluoromethoxylation of alcohols has been developed. This method generated an alkyl fluoroformate in situ from alcohols, followed by nucleophilic trifluoromethoxylation with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. The reaction is operationally simple and scalable, and it proceeds under mild reaction conditions to provide access to a wide range of trifluoromethyl ethers from alcohols. In addition, this method is suitable for the late‐stage trifluoromethoxylation of complex small molecules.