Premium
Synthesis of Difluoromethylthioesters from Aldehydes
Author(s) -
Guo ShiHuan,
Zhang XingLong,
Pan GaoFei,
Zhu XueQing,
Gao YaRu,
Wang YongQiang
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201710731
Subject(s) - chemistry , combinatorial chemistry , substrate (aquarium) , scope (computer science) , surface modification , reaction conditions , functional group , organic chemistry , nanotechnology , catalysis , computer science , materials science , polymer , programming language , oceanography , geology
Abstract Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late‐stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.