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Macrolide Synthesis through Intramolecular Oxidative Cross‐Coupling of Alkenes
Author(s) -
Jiang Bing,
Zhao Meng,
Li ShuSen,
Xu YunHe,
Loh TeckPeng
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201710601
Subject(s) - intramolecular force , moiety , chemistry , diene , stereoselectivity , conjugated diene , conjugated system , oxidative coupling of methane , oxidative phosphorylation , combinatorial chemistry , coupling reaction , stereochemistry , photochemistry , catalysis , organic chemistry , biochemistry , natural rubber , polymer , monomer
A Rh III ‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure.
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