Premium
Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines
Author(s) -
Yu Jiao,
Lin JinHong,
Xiao JiChang
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201710186
Subject(s) - difluorocarbene , fluoride , chemistry , primary (astronomy) , organic chemistry , medicinal chemistry , polymer chemistry , inorganic chemistry , physics , astronomy
The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o ‐phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one‐pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.