Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines | Zendy

Yu Jiao | Zendy; Lin JinHong | Zendy; Xiao JiChang | Zendy

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Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

Author(s) -

Yu Jiao,

Lin JinHong,

Xiao JiChang

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201710186

Subject(s) - difluorocarbene , fluoride , chemistry , primary (astronomy) , organic chemistry , medicinal chemistry , polymer chemistry , inorganic chemistry , physics , astronomy

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o ‐phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one‐pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.

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