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Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles
Author(s) -
Li Bowen,
Xie Jingyi,
Yuan Zhefan,
Jain Priyesh,
Lin Xiaojie,
Wu Kan,
Jiang Shaoyi
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201710068
Subject(s) - immune system , ethylene glycol , lipopolysaccharide , in vivo , chemistry , peg ratio , peripheral blood mononuclear cell , in vitro , polymer , biophysics , materials science , immunology , biochemistry , biology , organic chemistry , microbiology and biotechnology , finance , economics
Abstract While hydrophobic nanoparticles (NPs) have been long recognized to boost the immune activation, whether hydrophilic NPs modulate an immune system challenged by immune stimulators and how their hydrophilic properties may affect the immune response is still unclear. To answer this question, three polymers, poly(ethylene glycol) (PEG), poly(sulfobetaine) (PSB) and poly(carboxybetaine) (PCB), which are commonly considered hydrophilic, are studied in this work. For comparison, nanogels with uniform size and homogeneous surface functionalities were made from these polymers. Peripheral blood mononuclear cells (PBMCs) stimulated by lipopolysaccharide (LPS) and an LPS‐induced lung inflammation murine model were used to investigate the influence of nanogels on the immune system. Results show that the treatment of hydrophilic nanogels attenuated the immune responses elicited by LPS both in vitro and in vivo. Moreover, we found that PCB nanogels, which have the strongest hydration and the lowest non‐specific protein binding, manifested the best performance in alleviating the immune activation, followed by PSB and PEG nanogels. This reveals that the immunomodulatory effect of hydrophilic materials is closely related to their hydration characteristics and their ability to resist non‐specific binding in complex media.