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Cobalt‐Catalyzed Suzuki Biaryl Coupling of Aryl Halides
Author(s) -
Asghar Soneela,
Tailor Sanita B.,
Elorriaga David,
Bedford Robin B.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201710053
Subject(s) - aryl , cobalt , catalysis , halide , chemistry , carbene , combinatorial chemistry , suzuki reaction , coupling (piping) , palladium , organic chemistry , medicinal chemistry , alkyl , materials science , metallurgy
Readily accessed cobalt pre‐catalysts with N‐heterocyclic carbene ligands catalyze the Suzuki cross‐coupling of aryl chlorides and bromides with alkyllithium‐activated arylboronic pinacolate esters. Preliminary mechanistic studies indicate that the cobalt species is reduced to Co 0 during the reaction.
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