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Blockable Zn 10 L 15 Ion Channels through Subcomponent Self‐Assembly
Author(s) -
Haynes Cally J. E.,
Zhu Jinbo,
Chimerel Catalin,
HernándezAinsa Silvia,
Riddell Imogen A.,
Ronson Tanya K.,
Keyser Ulrich F.,
Nitschke Jonathan R.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201709544
Subject(s) - chemistry , lipid bilayer , membrane , ion , sodium dodecyl sulfate , sulfate , metal ions in aqueous solution , ion transporter , prism , metal , self assembly , inorganic chemistry , ion channel , chloride , chromatography , organic chemistry , biochemistry , physics , receptor , optics
Metal–organic anion channels based on Zn 10 L 15 pentagonal prisms have been prepared by subcomponent self‐assembly. The insertion of these prisms into lipid membranes was investigated by ion‐current and fluorescence measurements. The channels were found to mediate the transport of Cl − anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn 10 L 15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.