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Platelet‐Facilitated Photothermal Therapy of Head and Neck Squamous Cell Carcinoma
Author(s) -
Rao Lang,
Bu LinLin,
Ma Liang,
Wang Wenbiao,
Liu Huiqin,
Wan Da,
Liu JianFeng,
Li Andrew,
Guo ShiShang,
Zhang Lu,
Zhang WenFeng,
Zhao XingZhong,
Sun ZhiJun,
Liu Wei
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201709457
Subject(s) - photothermal therapy , head and neck squamous cell carcinoma , electroporation , platelet , cancer research , cancer , head and neck cancer , chemistry , medicine , nanotechnology , materials science , gene , biochemistry
Here, we present a platelet‐facilitated photothermal tumor therapy (PLT‐PTT) strategy, in which PLTs act as carriers for targeted delivery of photothermal agents to tumor tissues and enhance the PTT effect. Gold nanorods (AuNRs) were first loaded into PLTs by electroporation and the resulting AuNR‐loaded PLTs (PLT‐AuNRs) inherited long blood circulation and cancer targeting characteristics from PLTs and good photothermal property from AuNRs. Using a gene‐knockout mouse model, we demonstrate that the administration of PLT‐AuNRs and localizing laser irradiation could effectively inhibit the growth of head and neck squamous cell carcinoma (HNSCC). In addition, we found that the PTT treatment augmented PLT‐AuNRs targeting to the tumor sites and in turn, improved the PTT effects in a feedback manner, demonstrating the unique self‐reinforcing characteristic of PLT‐PTT in cancer therapy.