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Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst
Author(s) -
Kumar Amit,
EspinosaJalapa Noel Angel,
Leitus Gregory,
DiskinPosner Yael,
Avram Liat,
Milstein David
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201709180
Subject(s) - pincer movement , chemistry , manganese , catalysis , primary (astronomy) , organic chemistry , combinatorial chemistry , coupling (piping) , base (topology) , metal , materials science , mathematical analysis , physics , mathematics , astronomy , metallurgy
The first example of base‐metal‐catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom‐economical and sustainable.