Catalytic Enantioselective Double Carbopalladation/C−H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach

Combining a catalytic enantioselective reaction with dimerization in a single operation is an efficient way to upgrade the enantiomeric excesses ( ee ) of the product. Palladium‐catalyzed reaction of N ‐(2‐iodophenyl)‐ N ‐methyl methacrylamide derivatives with oxadiazole afforded, by a double enantioselective carbopalladation/intermolecular heteroarene C−H alkylation sequence, homodimers in good yields with excellent ee  values. The dimer was subsequently elaborated to the monomer in which the linker (oxadiazole) was incorporated into the target product.