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Bifurcated Nickel‐Catalyzed Functionalizations: Heteroarene C−H Activation with Allenes
Author(s) -
Nakanowatari Sachiyo,
Müller Thomas,
Oliveira João C. A.,
Ackermann Lutz
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201709087
Subject(s) - chemoselectivity , chemistry , catalysis , nickel , carbene , ligand (biochemistry) , combinatorial chemistry , imidazole , scope (computer science) , homogeneous catalysis , catalytic cycle , stereochemistry , organic chemistry , receptor , biochemistry , computer science , programming language
A unified strategy for nickel(0)‐catalyzed C−H allylations, alkenylations, and dienylations has been realized through versatile hydroarylations of allenes with ample scope. Thus, an inexpensive nickel catalyst modified with a N ‐heterocyclic carbene ligand enabled the direct transformation of C−H bonds of biologically relevant imidazole and purine derivatives with full control of regio‐ and chemoselectivity.