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Biomimetic Peptide‐Gated Nanoporous Membrane for On‐Demand Molecule Transport
Author(s) -
Xiao Kai,
Wu Kai,
Chen Lu,
Kong XiangYu,
Zhang Yuqi,
Wen Liping,
Jiang Lei
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201708695
Subject(s) - nanoporous , membrane , gating , nanotechnology , on demand , molecule , peptide , biophysics , drug delivery , chemistry , function (biology) , small molecule , materials science , biochemistry , computer science , microbiology and biotechnology , organic chemistry , multimedia , biology
Abstract The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membranes, with nanoscopic pores, high porosity, uniform pore dimensions, and controllable surface chemical properties, hold tremendous potential to achieve this function. Herein, we report a nano‐gating system for on‐demand molecule transport based on a peptide‐gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on‐demand on–off states via reversible conformational switching of the peptides. This nano‐gating system offers sustained release and can be used as a sophisticated molecule transport platform for localized drug delivery with a feedback function.