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Titanocene‐Catalyzed Radical Opening of N‐Acylated Aziridines
Author(s) -
Zhang YongQiang,
Vogelsang Elisabeth,
Qu ZhengWang,
Grimme Stefan,
Gansäuer Andreas
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707673
Subject(s) - catalysis , chemistry , acylation , conjugate , ring (chemistry) , radical , reaction mechanism , medicinal chemistry , electron transfer , photochemistry , organic chemistry , mathematical analysis , mathematics
Aziridines activated by N‐acylation are opened to the higher substituted radical through electron transfer from titanocene(III) complexes in a novel catalytic reaction. This reaction is applicable in conjugate additions, reductions, and cyclizations and suited for the construction of quaternary carbon centers. The concerted mechanism of the ring opening is indicated by DFT calculations.