Synthesis of Bicyclo[ n .1.0]alkanes by a Cobalt‐Catalyzed Multiple C(sp 3 )−H Activation Strategy | Zendy

Zhang ZhuoZhuo | Zendy; Han YeQiang | Zendy; Zhan BeiBei | Zendy; Wang Sai | Zendy; Shi BingFeng | Zendy

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Synthesis of Bicyclo[ n .1.0]alkanes by a Cobalt‐Catalyzed Multiple C(sp 3 )−H Activation Strategy

Author(s) -

Zhang ZhuoZhuo,

Han YeQiang,

Zhan BeiBei,

Wang Sai,

Shi BingFeng

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201707638

Subject(s) - bicyclic molecule , cobalt , catalysis , chemistry , methylene , hexane , stereochemistry , medicinal chemistry , organic chemistry

A cobalt‐catalyzed dual C(sp 3 )−H activation strategy has been developed and it provides a novel strategy for the synthesis of bicyclo[4.1.0]heptanes and bicyclo[3.1.0]hexanes. A key to the success of this reaction is the conformation‐induced methylene C(sp 3 )−H activation of the resulting cobaltabicyclo[4.n.1] intermediate. In addition, the synthesis of bicyclo[3.1.0]hexane from pivalamide, by a triple C(sp 3 )−H activation, has also been demonstrated.

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