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Synthesis of Bicyclo[ n .1.0]alkanes by a Cobalt‐Catalyzed Multiple C(sp 3 )−H Activation Strategy
Author(s) -
Zhang ZhuoZhuo,
Han YeQiang,
Zhan BeiBei,
Wang Sai,
Shi BingFeng
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707638
Subject(s) - bicyclic molecule , cobalt , catalysis , chemistry , methylene , hexane , stereochemistry , medicinal chemistry , organic chemistry
A cobalt‐catalyzed dual C(sp 3 )−H activation strategy has been developed and it provides a novel strategy for the synthesis of bicyclo[4.1.0]heptanes and bicyclo[3.1.0]hexanes. A key to the success of this reaction is the conformation‐induced methylene C(sp 3 )−H activation of the resulting cobaltabicyclo[4.n.1] intermediate. In addition, the synthesis of bicyclo[3.1.0]hexane from pivalamide, by a triple C(sp 3 )−H activation, has also been demonstrated.