Premium
Remote Loading of Small‐Molecule Therapeutics into Cholesterol‐Enriched Cell‐Membrane‐Derived Vesicles
Author(s) -
Zhang Xinxin,
Angsantikul Pavimol,
Ying Man,
Zhuang Jia,
Zhang Qiangzhe,
Wei Xiaoli,
Jiang Yao,
Zhang Yue,
Dehaini Diana,
Chen Mengchun,
Chen Yijie,
Gao Weiwei,
Fang Ronnie H.,
Zhang Liangfang
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707598
Subject(s) - nanocarriers , nanomedicine , biocompatibility , membrane , drug delivery , in vivo , nanotechnology , chemistry , vesicle , doxorubicin , biophysics , materials science , nanoparticle , biochemistry , medicine , biology , microbiology and biotechnology , surgery , organic chemistry , chemotherapy
The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use of naturally derived cell membranes, which can bestow nanocarriers with cell‐specific functionalities. Herein, we report on a strategy enabling efficient encapsulation of drugs via remote loading into membrane vesicles derived from red blood cells. This is accomplished by supplementing the membrane with additional cholesterol, stabilizing the nanostructure and facilitating the retention of a pH gradient. We demonstrate the loading of two model drugs: the chemotherapeutic doxorubicin and the antibiotic vancomycin. The therapeutic implications of these natural, remote‐loaded nanoformulations are studied both in vitro and in vivo using animal disease models. Ultimately, this approach could be used to design new biomimetic nanoformulations with higher efficacy and improved safety profiles.