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Homo‐ and Heteroleptic Phototoxic Dinuclear Metallo‐Intercalators Based on Ru II (dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies
Author(s) -
Saeed Hiwa K.,
Jarman Paul J.,
Archer Stuart,
Sreedharan Sreejesh,
Saeed Ibrahim Q.,
Mckenzie Luke K.,
Weinstein Julia A.,
Buurma Niklaas J.,
Smythe Carl G. W.,
Thomas Jim A.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707350
Subject(s) - intercalation (chemistry) , phototoxicity , homoleptic , chemistry , singlet oxygen , luminescence , stereochemistry , luminescent measurements , photochemistry , oxygen , materials science , metal , in vitro , inorganic chemistry , organic chemistry , biochemistry , optoelectronics
Using a new mononuclear “building block,” for the first time, a dinuclear Ru II (dppn) complex and a heteroleptic system containing both Ru II (dppz) and Ru II (dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1 O 2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.