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Synthesis of [ 18 F]Fluoroarenes by Nucleophilic Radiofluorination of N ‐Arylsydnones
Author(s) -
Narayanam Maruthi Kumar,
Ma Gaoyuan,
Champagne Pier Alexandre,
Houk Kendall N.,
Murphy Jennifer M.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707274
Subject(s) - regioselectivity , chemistry , nucleophile , combinatorial chemistry , fluoride , medicinal chemistry , organic chemistry , inorganic chemistry , catalysis
A practical method for radiofluorination of anilines with [ 18 F]fluoride via N ‐arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18 F‐labeling to prepare [ 18 F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18 F‐labeled neuropeptide.