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Reagent‐Free C−H/N−H Cross‐Coupling: Regioselective Synthesis of N‐Heteroaromatics from Biaryl Aldehydes and NH 3
Author(s) -
Zhao HuaiBo,
Liu ZhanJiang,
Song Jinshuai,
Xu HaiChao
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707192
Subject(s) - regioselectivity , chemistry , reagent , electrosynthesis , oxidizing agent , combinatorial chemistry , nitrogen atom , organic chemistry , catalysis , electrochemistry , ring (chemistry) , electrode
An unprecedented synthesis of N‐heteroaromatics from biaryl aldehydes and NH 3 through reagent‐free C−H/N−H cross‐coupling has been developed. The electrosynthesis uses NH 3 as an inexpensive and atom‐economic nitrogen donor, requires no oxidizing agents, and allows efficient and regioselective access to a wide range of phenanthridines and structurally related polycyclic N‐heteroaromatic products.