Premium
Reagent‐Free C−H/N−H Cross‐Coupling: Regioselective Synthesis of N‐Heteroaromatics from Biaryl Aldehydes and NH 3
Author(s) -
Zhao HuaiBo,
Liu ZhanJiang,
Song Jinshuai,
Xu HaiChao
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707192
Subject(s) - regioselectivity , chemistry , reagent , electrosynthesis , oxidizing agent , combinatorial chemistry , nitrogen atom , organic chemistry , catalysis , electrochemistry , ring (chemistry) , electrode
An unprecedented synthesis of N‐heteroaromatics from biaryl aldehydes and NH 3 through reagent‐free C−H/N−H cross‐coupling has been developed. The electrosynthesis uses NH 3 as an inexpensive and atom‐economic nitrogen donor, requires no oxidizing agents, and allows efficient and regioselective access to a wide range of phenanthridines and structurally related polycyclic N‐heteroaromatic products.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom