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Wacker‐Type Oxidation Using an Iron Catalyst and Ambient Air: Application to Late‐Stage Oxidation of Complex Molecules
Author(s) -
Liu Binbin,
Jin Fengli,
Wang Tianjiao,
Yuan Xiaorong,
Han Wei
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201707006
Subject(s) - wacker process , catalysis , reagent , chemistry , molecule , combinatorial chemistry , organic chemistry , photochemistry , palladium
Abstract A practical and general iron‐catalyzed Wacker‐type oxidation of olefins to ketones is presented, and it uses ambient air as the sole oxidant. The mild oxidation conditions enable exceptional functional‐group tolerance, which has not been demonstrated for any other Wacker‐type reaction to date. The inexpensive and nontoxic reagents [iron(II) chloride, polymethylhydrosiloxane, and air] can, therefore, also be employed to oxidize complex natural‐product‐derived and polyfunctionalized molecules.