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Buchwald–Hartwig Amination of Nitroarenes
Author(s) -
Inoue Fumiyoshi,
Kashihara Myuto,
Yadav M. Ramu,
Nakao Yoshiaki
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201706982
Subject(s) - amination , chemistry , palladium , phosphine , amine gas treating , catalysis , stoichiometry , organic chemistry , catalytic cycle , oxidative coupling of methane , medicinal chemistry , combinatorial chemistry
Abstract The Buchwald–Hartwig amination of nitroarenes was achieved for the first time by using palladium catalysts bearing dialkyl(biaryl)phosphine ligands. These cross‐coupling reactions of nitroarenes with diarylamines, arylamines, and alkylamines afforded the corresponding substituted arylamines. A catalytic cycle involving the oxidative addition of the Ar−NO 2 bond to palladium(0) followed by nitrite/amine exchange is proposed based on a stoichiometric reaction.