Premium
Fluorinative Rearrangements of Substituted Phenylallenes Mediated by (Difluoroiodo)toluene: Synthesis of α‐(Difluoromethyl)styrenes
Author(s) -
Zhao Zhensheng,
Racicot Léanne,
Murphy Graham K.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201706798
Subject(s) - allene , toluene , chemistry , regioselectivity , yield (engineering) , fluorine , medicinal chemistry , catalysis , organic chemistry , materials science , metallurgy
Abstract Phenylallenes undergo fluorinative rearrangement upon the action of (difluoroiodo)toluene in the presence of 20 mol % BF 3 ⋅OEt 2 to yield α‐difluoromethyl styrenes. This unprecedented reaction was entirely chemoselective for the internal allene π bond, and showed remarkable regioselectivity during the fluorination event. Substituted phenylallenes, phenylallenes possessing both phenyl‐ and α‐allenyl substituents, and diphenylallenes were investigated, and good functional‐group compatibility was observed throughout. The ease with which allenes can be prepared on a large scale, and the operational simplicity of this reaction allowed us to rapidly access fluorine‐containing building blocks that have not been accessed by conventional deoxyfluorination strategies.