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Palladium‐Catalyzed Spirocyclization through C−H Activation and Regioselective Alkyne Insertion
Author(s) -
Yoon Hyung,
Rölz Martin,
Landau Felicitas,
Lautens Mark
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201706325
Subject(s) - regioselectivity , alkyne , intramolecular force , palladium , chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry
A Pd‐catalyzed spirocyclization involving a sequential carbopalladation, intramolecular C−H activation, and a highly regioselective alkyne insertion to afford spirooxindoles and spirodihydrobenzofurans has been achieved. The spirocyclic products were generated in good to excellent yields with complete regiocontrol in a readily scalable procedure.