Premium
Ultrathin Cell‐Membrane‐Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection
Author(s) -
Liu Xiaomeng,
Xiao Tongfang,
Wu Fei,
Shen MoYuan,
Zhang Meining,
Yu Hsiaohua,
Mao Lanqun
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201705900
Subject(s) - microelectrode , phosphorylcholine , nanotechnology , biomolecule , materials science , in vivo , membrane , coating , polymer , biophysics , chemistry , electrode , biochemistry , microbiology and biotechnology , composite material , biology
Resisting biomolecule adsorption onto the surface of brain‐implanted microelectrodes is a key issue for in vivo monitoring of neurochemicals. Herein, we demonstrate that an ultrathin cell‐membrane‐mimic film of ethylenedioxythiophene tailored with zwitterionic phosphorylcholine (EDOT‐PC) electropolymerized onto the surface of a carbon fiber microelectrode (CFE) not only resists protein adsorption but also maintains the sensitivity and time response for in vivo monitoring of dopamine (DA). As a consequence, the as‐prepared PEDOT‐PC/CFEs could be used as a new reliable platform for tracking DA in vivo and would help understand the physiological and pathological functions of DA.