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Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes
Author(s) -
Bao Xu,
Wang Qian,
Zhu Jieping
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201705641
Subject(s) - enantioselective synthesis , chemistry , palladium , alkylation , intramolecular force , phosphine , catalysis , denticity , heck reaction , ligand (biochemistry) , medicinal chemistry , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor
A palladium‐catalyzed reaction of γ,δ‐unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C−H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).