Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes | Zendy

Bao Xu | Zendy; Wang Qian | Zendy; Zhu Jieping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes

Author(s) -

Bao Xu,

Wang Qian,

Zhu Jieping

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201705641

Subject(s) - enantioselective synthesis , chemistry , palladium , alkylation , intramolecular force , phosphine , catalysis , denticity , heck reaction , ligand (biochemistry) , medicinal chemistry , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor

A palladium‐catalyzed reaction of γ,δ‐unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C−H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research