Manganese(I)‐Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand | Zendy

Garbe Marcel | Zendy; Junge Kathrin | Zendy; Walker Svenja | Zendy; Wei Zhihong | Zendy; Jiao Haijun | Zendy; Spannenberg Anke | Zendy; Bachmann Stephan | Zendy; Scalone Michelangelo | Zendy; Beller Matthias | Zendy

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Manganese(I)‐Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand

Author(s) -

Garbe Marcel,

Junge Kathrin,

Walker Svenja,

Wei Zhihong,

Jiao Haijun,

Spannenberg Anke,

Bachmann Stephan,

Scalone Michelangelo,

Beller Matthias

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201705471

Subject(s) - pincer movement , enantioselective synthesis , pincer ligand , chemistry , catalysis , manganese , ligand (biochemistry) , selectivity , noyori asymmetric hydrogenation , asymmetric hydrogenation , chiral ligand , hydrogen , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry

A new chiral manganese PNP pincer complex is described. The asymmetric hydrogenation of several prochiral ketones with molecular hydrogen in the presence of this complex proceeds under mild conditions (30–40 °C, 4 h, 30 bar H 2 ). Besides high catalytic activity for aromatic substrates, aliphatic ketones are hydrogenated with remarkable selectivity (e.r. up to 92:8). DFT calculations support an outer sphere hydrogenation mechanism as well as the experimentally determined stereochemistry.

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