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Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919‐2
Author(s) -
Cheng Bichu,
Müller Rolf,
Trauner Dirk
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201705387
Subject(s) - gram , total synthesis , chemistry , absolute configuration , stereochemistry , bacteria , biology , genetics
The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram‐positive and Gram‐negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919‐2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919‐2.