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Palladium‐Catalyzed Fluoroarylation of gem ‐Difluoroalkenes
Author(s) -
Tang HaiJun,
Lin LingZhi,
Feng Chao,
Loh TeckPeng
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201705321
Subject(s) - chemistry , palladium , aryl , catalysis , halide , nucleophile , combinatorial chemistry , fluoride , base (topology) , nucleophilic substitution , leaving group , medicinal chemistry , organic chemistry , inorganic chemistry , alkyl , mathematics , mathematical analysis
A Pd‐catalyzed fluoroarylation of gem ‐difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α‐CF 3 ‐benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem ‐difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non‐symmetric α,α‐disubstituted trifluoroethane derivatives.