Highly Selective Artificial Potassium Ion Channels Constructed from Pore‐Containing Helical Oligomers | Zendy

Lang Chao | Zendy; Deng Xiaoli | Zendy; Yang Feihu | Zendy; Yang Bing | Zendy; Wang Wei | Zendy; Qi Shuaiwei | Zendy; Zhang Xin | Zendy; Zhang Chenyang | Zendy; Dong Zeyuan | Zendy; Liu Junqiu | Zendy

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Highly Selective Artificial Potassium Ion Channels Constructed from Pore‐Containing Helical Oligomers

Author(s) -

Lang Chao,

Deng Xiaoli,

Yang Feihu,

Yang Bing,

Wang Wei,

Qi Shuaiwei,

Zhang Xin,

Zhang Chenyang,

Dong Zeyuan,

Liu Junqiu

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201705048

Subject(s) - chemistry , transmembrane channels , oligomer , kcsa potassium channel , ion channel , ion , stacking , membrane , potassium channel , potassium , ion transporter , transmembrane protein , selectivity , crystallography , biophysics , voltage gated ion channel , polymer chemistry , organic chemistry , biochemistry , receptor , biology , catalysis

Potassium ion channels specifically transport K + ions over Na + ions across a cell membrane. A queue of four binding sites in the K + channel pore plays significant roles during highly selective conduction. A kind of aromatic helical oligomer was synthesized that can selectively bind K + over Na + . By aromatic stacking of helical oligomers, a type of artificial K + channels with contiguous K + binding sites was constructed. Such artificial channels exhibited exceptionally high K + /Na + selectivity ratios during transmembrane ion conduction.

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