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Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine‐Based Probe
Author(s) -
Waghorn Philip A.,
Jones Chloe M.,
Rotile Nicholas J.,
Koerner Steffi K.,
Ferreira Diego S.,
Chen Howard H.,
Probst Clemens K.,
Tager Andrew M.,
Caravan Peter
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201704773
Subject(s) - magnetic resonance imaging , extracellular matrix , gadolinium , pathology , chemistry , lung , nuclear magnetic resonance , medicine , radiology , biochemistry , physics , organic chemistry
Fibrogenesis is the active production of extracellular matrix in response to tissue injury. In many chronic diseases persistent fibrogenesis results in the accumulation of scar tissue, which can lead to organ failure and death. However, no non‐invasive technique exists to assess this key biological process. All tissue fibrogenesis results in the formation of allysine, which enables collagen cross‐linking and leads to tissue stiffening and scar formation. We report herein a novel allysine‐binding gadolinium chelate (GdOA), that can non‐invasively detect and quantify the extent of fibrogenesis using magnetic resonance imaging (MRI). We demonstrate that GdOA signal enhancement correlates with the extent of the disease and is sensitive to a therapeutic response.