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Manganese‐Catalyzed C−H Functionalizations: Hydroarylations and Alkenylations Involving an Unexpected Heteroaryl Shift
Author(s) -
Wang Chengming,
Wang Ai,
Rueping Magnus
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201704682
Subject(s) - manganese , chemistry , stereoselectivity , catalysis , surface modification , aryl , bond cleavage , cascade , combinatorial chemistry , cleavage (geology) , medicinal chemistry , stereochemistry , organic chemistry , materials science , alkyl , fracture (geology) , chromatography , composite material
A manganese‐catalyzed regio‐ and stereoselective hydroarylation of allenes is reported. The C−H functionalization method provides access to various alkenylated indoles in excellent yields. Moreover, a hydroarylation/cyclization cascade involving an unexpected C−N bond cleavage and aryl shift has been developed, which provides a new synthetic approach to substituted pyrroloindolones.