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Catalytic Oxidative Trifluoromethoxylation of Allylic C−H Bonds Using a Palladium Catalyst
Author(s) -
Qi Xiaoxu,
Chen Pinhong,
Liu Guosheng
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201703841
Subject(s) - allylic rearrangement , catalysis , palladium , chemistry , benzoquinone , intermolecular force , medicinal chemistry , combinatorial chemistry , photochemistry , organic chemistry , molecule
A catalytic intermolecular allylic C−H trifluoromethoxylation reaction of alkenes has been developed based on the use of a palladium catalyst, CsOCF 3 as the trifluoromethoxide source, and benzoquinone as the oxidant. This reaction provides an efficient route for directly accessing allylic trifluoromethoxy derivatives with excellent regioselectivities from terminal alkenes via an allylic C−H bond activation process.
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