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1‐Substituted 2‐Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
Author(s) -
Kirichok Alexander A.,
Shton Iryna,
Kliachyna Maria,
Pishel Iryna,
Mykhailiuk Pavel K.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201703801
Subject(s) - piperidine , drug discovery , drug , chemistry , combinatorial chemistry , stereochemistry , pharmacology , medicine , biochemistry
The 2‐substituted piperidine core is found in drugs (18 FDA‐approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2‐substituted piperidines and a demonstration of their validation in drug discovery.