Premium
Antimonene Quantum Dots: Synthesis and Application as Near‐Infrared Photothermal Agents for Effective Cancer Therapy
Author(s) -
Tao Wei,
Ji Xiaoyuan,
Xu Xiaoding,
Islam Mohammad Ariful,
Li Zhongjun,
Chen Si,
Saw Phei Er,
Zhang Han,
Bharwani Zameer,
Guo Zilei,
Shi Jinjun,
Farokhzad Omid C.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201703657
Subject(s) - photothermal therapy , biocompatibility , nanomaterials , polyethylene glycol , nanotechnology , exfoliation joint , materials science , cancer therapy , peg ratio , surface modification , graphene , chemistry , cancer , medicine , organic chemistry , finance , economics , metallurgy
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)‐based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two‐dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG‐coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs‐based PTAs such as graphene, Au, MoS 2 , and black phosphorus (BP). The AMQDs‐based PTAs also exhibited a unique feature of NIR‐induced rapid degradability. Through both in vitro and in vivo studies, the PEG‐coated AMQDs demonstrated notable NIR‐induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.