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DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization
Author(s) -
Reile Indrek,
Aspers Ruud L. E. G.,
Tyburn JeanMax,
Kempf James G.,
Feiters Martin C.,
Rutjes Floris P. J. T.,
Tessari Marco
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201703577
Subject(s) - hyperpolarization (physics) , chemistry , analyte , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , spin isomers of hydrogen , spectroscopy , chromatography , organic chemistry , hydrogen , physics , quantum mechanics
DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low‐micromolar mixtures, thus reducing the concentration requirements by at least 100‐fold.