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Biomimetic Total Synthesis of (±)‐Homodimericin A
Author(s) -
Ma Donghui,
Liu Yangbin,
Wang Zhang
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702775
Subject(s) - cascade , intramolecular force , total synthesis , biomimetic synthesis , chemistry , sequence (biology) , combinatorial chemistry , aqueous solution , cascade reaction , stereochemistry , organic chemistry , catalysis , biochemistry , chromatography
A biomimetic total synthesis of racemic homodimericin A was achieved in seven steps, including two cascade reactions. Aqueous buffer solutions are found to help both the oxidative dimerization cascade and the intramolecular Diels–Alder cascade. This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A.