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Oxidative Neutralization of Mustard‐Gas Simulants in an On‐Board Flow Device with In‐Line NMR Monitoring
Author(s) -
Picard Baptiste,
Gouilleux Boris,
Lebleu Thomas,
Maddaluno Jacques,
Chataigner Isabelle,
Penhoat Maël,
Felpin FrançoisXavier,
Giraudeau Patrick,
Legros Julien
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702744
Subject(s) - neutralization , chemistry , reagent , hydrogen sulfide , hydrogen peroxide , continuous flow , sulfide , adduct , nuclear chemistry , organic chemistry , sulfur , physics , mechanics , antibody , immunology , biology
The fast and effective neutralization of the mustard‐gas simulant 2‐chloroethyl ethyl sulfide (CEES) using a simple and portable continuous flow device is reported. Neutralization takes place through a fully selective sulfoxidation by a stable source of hydrogen peroxide (alcoholic solution of urea–H 2 O 2 adduct/MeSO 3 H freshly prepared). The reaction progress can be monitored with an in‐line benchtop NMR spectrometer, allowing a real‐time adjustment of reaction conditions. Inherent features of millireactors, that is, perfect control of mixing, heat and reaction time, allowed the neutralization of 25 g of pure CEES within 46 minutes in a 21.5 mL millireactor ( t R =3.9 minutes). This device, which relies on affordable and nontoxic reagents, fits into a suitcase, and can be deployed by police/military forces directly on the attack site.