Ligand‐Enabled Auxiliary‐Free  meta ‐C−H Arylation of Phenylacetic Acids | Zendy

Li GenCheng | Zendy; Wang Peng | Zendy; Farmer Marcus E. | Zendy; Yu JinQuan | Zendy

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Ligand‐Enabled Auxiliary‐Free meta ‐C−H Arylation of Phenylacetic Acids

Author(s) -

Li GenCheng,

Wang Peng,

Farmer Marcus E.,

Yu JinQuan

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201702686

Subject(s) - phenylacetic acid , chemistry , mandelic acid , ligand (biochemistry) , aryl , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , alkyl

The meta ‐C−H arylation of free phenylacetic acid was realized using 2‐carbomethoxynorbornene (NBE‐CO 2 Me) as a transient mediator. Both the modified norbornene and the mono‐protected 3‐amino‐2‐hydroxypyridine type ligand are crucial for this auxiliary‐free meta ‐C−H arylation reaction. A series of phenylacetic acids, including mandelic acid and phenylglycine, react smoothly with various aryl iodides to provide the meta ‐arylated products in high yields.

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