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Enantioselective Borylation of Aromatic C−H Bonds with Chiral Dinitrogen Ligands
Author(s) -
Su Bo,
Zhou TaiGang,
Xu PeiLin,
Shi ZhangJie,
Hartwig John F.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702628
Subject(s) - borylation , enantioselective synthesis , chemistry , iridium , oxazoline , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , alkyl , aryl
The borylation of C−H bonds catalyzed by transition metals has been investigated extensively in the past two decades, but no iridium‐catalyzed enantioselective borylation of C−H bonds has been reported. We report a set of iridium‐catalyzed enantioselective borylations of aromatic C−H bonds. This reaction relies on a set of newly developed chiral quinolyl oxazoline ligands. This process proceeds under mild conditions with good to excellent enantioselectivity, and the borylated products can be converted to enantioenriched derivatives containing new C−O, C−C, C−Cl, or C−Br bonds.