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Amide‐Directed C−H Sodiation by a Sodium Hydride/Iodide Composite
Author(s) -
Huang Yinhua,
Chan Guo Hao,
Chiba Shunsuke
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702512
Subject(s) - iodide , sodium hydride , lithium amide , sodium iodide , chemistry , amide , lithium iodide , lithium (medication) , hydride , sodium , lithium hydride , medicinal chemistry , organic chemistry , catalysis , hydrogen , ion , ionic bonding , enantioselective synthesis , medicine , electrode , endocrinology , electrolyte
A new protocol for amide‐directed ortho and lateral C−H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.