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B(C 6 F 5 ) 3 ‐Catalyzed Cascade Reduction of Pyridines
Author(s) -
Liu ZhiYun,
Wen ZhiHui,
Wang XiaoChen
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702304
Subject(s) - chemistry , hydrosilylation , nitrile , catalysis , ketone , cascade , hydroboration , combinatorial chemistry , nitro , reagent , realization (probability) , reduction (mathematics) , functional group , cascade reaction , organic chemistry , medicinal chemistry , mathematics , geometry , chromatography , alkyl , statistics , polymer
Abstract B(C 6 F 5 ) 3 has been found to be an effective catalyst for reduction of pyridines and other electron‐deficient N‐heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional‐group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.