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Hydroxoiridium‐Catalyzed Hydroalkylation of Terminal Alkenes with Ureas by C(sp 3 )−H Bond Activation
Author(s) -
Yamauchi Daisuke,
Nishimura Takahiro,
Yorimitsu Hideki
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201702169
Subject(s) - catalysis , chemistry , alkylation , medicinal chemistry , terminal (telecommunication) , stereochemistry , organic chemistry , telecommunications , computer science
Direct alkylation of a methyl group, on di‐ and trisubstituted ureas, with terminal alkenes by C(sp 3 )−H bond activation proceeded in the presence of a hydroxoiridium/bisphosphine catalyst to give high yields of the corresponding addition products. The hydroxoiridium/bisphosphine complex generates an amidoiridium intermediate by reaction with ureas having an N−H bond.