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Domino N ‐/ C ‐Arylation via In Situ Generation of a Directing Group: Atom‐Efficient Arylation Using Diaryliodonium Salts
Author(s) -
Teskey Christopher J.,
Sohel Shariar M. A.,
Bunting Danielle L.,
Modha Sachin G.,
Greaney Michael F.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201701523
Subject(s) - domino , aryl , chemistry , ruthenium , in situ , combinatorial chemistry , functional group , catalysis , cascade reaction , atom economy , group (periodic table) , atom (system on chip) , organic chemistry , alkyl , computer science , embedded system , polymer
Both aryl components of diaryliodonium salts can be used in a domino one‐pot reaction via in situ generation of a directing group. A number of heterocycles undergo N‐arylation which is followed by ruthenium‐catalyzed C‐arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.