Domino  N ‐/ C ‐Arylation via In Situ Generation of a Directing Group: Atom‐Efficient Arylation Using Diaryliodonium Salts | Zendy

Teskey Christopher J. | Zendy; Sohel Shariar M. A. | Zendy; Bunting Danielle L. | Zendy; Modha Sachin G. | Zendy; Greaney Michael F. | Zendy

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Domino N ‐/ C ‐Arylation via In Situ Generation of a Directing Group: Atom‐Efficient Arylation Using Diaryliodonium Salts

Author(s) -

Teskey Christopher J.,

Sohel Shariar M. A.,

Bunting Danielle L.,

Modha Sachin G.,

Greaney Michael F.

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201701523

Subject(s) - domino , aryl , chemistry , ruthenium , in situ , combinatorial chemistry , functional group , catalysis , cascade reaction , atom economy , group (periodic table) , atom (system on chip) , organic chemistry , alkyl , computer science , embedded system , polymer

Both aryl components of diaryliodonium salts can be used in a domino one‐pot reaction via in situ generation of a directing group. A number of heterocycles undergo N‐arylation which is followed by ruthenium‐catalyzed C‐arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

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