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Iridium‐Catalyzed Asymmetric Hydrogenation of Benzo[ b ]thiophene 1,1‐Dioxides
Author(s) -
Tosatti Paolo,
Pfaltz Andreas
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201701409
Subject(s) - iridium , benzothiophene , asymmetric hydrogenation , thiophene , chemistry , enantioselective synthesis , catalysis , phosphinite , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
An efficient iridium‐catalyzed asymmetric hydrogenation of substituted benzothiophene 1,1‐dioxides is described. The use of iridium complexes with chiral pyridyl phosphinite ligands provides access to highly enantiomerically enriched sulfones with substituents at the 2‐ and 3‐position. Sulfones of this type are of interest as core structures of agrochemicals and pharmaceuticals. Moreover, they can be further reduced to chiral 2,3‐dihydrobenzothiophenes.